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|Title:||Antioxidant and antimutagenic of Thai Ganodema lucidum|
|Keywords:||Thai Ganoderma lucidum;antioxidant;antimutagenic;Ames’test;cytotoxicity|
|Publisher:||The Thai Pharmacological and Therapeutic Society of Thailand.|
|Citation:||Thai J Pharmacol. 2010;32(1):307-309.|
|Abstract:||Thai Ganoderma lucidum (G2), which has been grown in Thailand as part of the Royal Project since 1988 was studied for its safety and efficacy. The present study aimed at comparing the fruiting body (whole fruiting) and mycelium of GL hot water extracts with regards to their in vitro mutagenic and antimutagenic potential by bacterial reverse mutation assay, antioxidant activity by free radical scavenging activity (DPPH assay), and iron chelating activity. The results showed that both GL extracts ranging from 0.15 to 3.0 mg/ml was neither mutagenic nor antimutagenic in bacterial system. Higher antioxidant activity in term of DPPH scavenging free radicals was found in fruiting body extract when compared with the mycelium extract. Moreover, both GL extracts showed a slight effect of chelating activity on Fe2+. Significantly, the antioxidant capacity correlated with the total phenolic content. While no tested concentrations of GL extracts were toxic to TA98 and TA100 salmonella typhimurium, the highest non-mutagenic concentration was cytotoxic to lung carcinoma cell lines (A549) as determined by Trypan blue assay. This is the first comparative study on the antimutagenic and antioxidant activities of Thai Ganoderma fruiting body and mycelium extracts. The information obtained from the study will provide useful information for safety profile of Thai GL and idea to select the GL parts to develop GL products that promote health and longevity or disease prevention.|
|Appears in Collections:||Pharmacology: National Journal Publications|
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