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|Title:||Inhibitory effect of methanol and hexane extracts of Moringa oleifera Lam leaves on NO production in LPS-activated microglia|
|Keywords:||Moringa oleifera Lam;Microglia;Nitric oxide|
|Publisher:||The Thai Pharmacological and Therapeutic Society of Thailand.|
|Citation:||Karachot B, Thampithak A, Jantaratnotai N, Jaisin Y, Meesarapee B, Tuchinda P, Sanvarinda Y. Inhibitory effect of methanol and hexane extracts of Moringa oleifera Lam leaves on NO production in LPS-activated microglia. Thai J Pharmacol 2010;32(1):152-155.|
|Abstract:||Moringa oleifera Lam (M.oleifra), is generally in tropical areas, South Asia and Thailand. It has been used for the treatment of various diseases including inflammation. However, little is known about its anti-inflammatory activity. We, therefore studied the effect of crude extracts from leaves (Methanol and hexane fractions) of M. oleifera on the production of nitric oxide (NO), a pro-inflammatory substance in highly aggressively proliferating immortalized (HAPI) microglial cells activated by lipopolysaccharide (LPS) and found that the extracts from M. oleifera significantly suppressed nitric oxide production in a dose dependent manner. This preliminary result demonstrates that the anti-inflammatory activity of the crude extracts of M. oleifera leaves is due partly through the inhibition of NO production and suggests that M. oleifera may have neuroprotective potential inneurodegenerative diseases caused by neuroinflammation.|
|Appears in Collections:||Chemistry: National Journal Publications|
Pharmacology: National Journal Publications
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