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Title: Protective effects of curcumin against dopamine quinone-induced dopaminergic neurotoxicity in SH-SY5Y cells
Authors: Benjawan Meesarapee
Yamaratee Jaisin
Noppawan Phumala Morales
Yupin Sanvarinda
Keywords: 6-OHDA;quinoprotein;curcuma longa
Issue Date: 2010
Publisher: The Pharmacological and Therapeutic Society of Thailand
Citation: Thai J Pharmacol. 2010;32(1):149-151.
Abstract: Auto-oxidation of 6-hydroxy dopamine (6-OHDA) has been known to generate free radicals and subsequent quinone proteins formation which is toxic to dopaminergic neurons. Curcumin, is a pure compound extracted from Curcuma longa which known to possess anti-oxidant, anti-inflammatory and anti-carcinogenic activities. In this study, we investigated the effects of curcumin on 6-OHDA-induced neurotoxicity in SH-SY5Y cells. It was found that curcumin significantly increased the viability of the cells. Along with the increase in cellsurvival the quinoprotein production was significantly decreased. These results indicate that curcumin has neuroprotective effects and may have a therapeutic potential for treatment of Parkinson disease.
ISSN: 0125-3832
Appears in Collections:Pharmacology: National Journal Publications

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