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|Title:||ANTI-OXIDATIVE STRESS ACTIVITY OF PHIKUD NAVAKOT EXTRACT IN SACCHAROMYCES CEREVISIAE|
|Keywords:||Anti-oxidant;Hydrogen peroxide;Phikud Navakot;Traditional drug;Yeast|
|Publisher:||The 30th Annual Research Conference in Pharmaceutical Sciences||
|Citation:||Thai Journal of Pharmaceutical Sciences 38(Suppl.) (2013);88-90|
|Abstract:||Phikud Navakot is a polyherbal formula in Yahom included in List of Herbal Medicinal Products A.D. 2012. Yahom is primarily used as cardiotonic agent to increase cardiac output according to Thai traditional knowledge. Scientific evidence demonstrating biological activity of Phikud Navakot has to be evaluated. Phikud Navakot comprises an equal weight of nine crude drugs namely Kot Soa [root of Angelica dahurica (Fisch.) Benth. & Hook. f.], Kot Khamao [rhizome of Atractylodes lancea (Thunb.) DC.], Kot Hua Bua (rhizome of Ligusticum chuanxiong Hort.), Kot Chiang [root of Angelica sinensis (Oliv.) Diels], Kot Chulalumpa (aerial part of Artemisia pallens Wall. ex Besser), Kot Kradook [rhizome of Saussurea costus (Falc.) Lipsch.], Kot Kan Prao (rhizome of Picrorhiza kurrooa Royle ex Benth.), Kot Pung Pla (gall of Terminalia chebula Retz.), and Kot Jatamansi [root and rhizome of Nardostachys jatamansi (D. Don) DC.]. Active compounds isolated from these herbs were found to exhibit antioxidant activity, for example, picroliv, picroside-I and kutkoside from P. kurrooa1, and ferulic acid from root of A. sinensis2. Oxidative stress is one contributing factor in development of several pathophysiological conditions including cardiovascular diseases, neurodegenerative diseases, cancer and aging3. Antioxidative stress activity at the cellular level of Phikud Navakot should be determined to support its traditional use. Saccharomyces cerevisiae is a model eukaryotic organism widely used in the study of cellular processes4,5. The present study was aimed to investigate the effect of Phikud Navakot extract against oxidative stress induced by hydrogen peroxide in yeast model.|
|Appears in Collections:||Microbiology: International Proceedings|
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