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Title: The anti-apoptosis effect of curcumin I on bax/bcl-2 ratio against 6-OHDA induced SH-SH-5Y toxicity
Authors: Piyanee Ratanachamnong
Sukumal Chongthammakun
Noppawan Phumala-Morales
Keywords: 6-OHDA;Curcumin I;Bax;Bcl-2;Phospho-P38
Issue Date: 2010
Publisher: สมาคมเภสัชวิทยาแห่งประเทศไทย
Citation: Thai J Pharmacol 2010;32(1):145-148.
Abstract: Curcumin is a naturally occurring polyphenolic compound. It has been reported that it exerts anti-oxidative and anti-apoptotic activities. 6-Hydroxydopamine (6-OHDA) is used as a neurotoxin to generate a model of Parkinson’s disease. In the present study, we investifate whether curcumin I (diferuloylmethane) could protect SH-SY5Y, dopaminergic cells from 6-OHDA-induced neurotoxicity. The results showed that pretreatment with curcumin I significantly prevented 6-OHDA induced cell viability reduction. Further experiments indicated that curcumin I could protect 6-OHDA-induced apoptosis signaling cascades activation. The results showed that pretreatment with curcumin I could prevent 6-OHDA-induced increasing of Bax/Bcl-2 ratio. This study suggested that curcumin I exerts its protective effects against 6-OHDA induced neurotoxicity. Therefore, curcumin I may be used as a potential compound for preventing oxidative stress-induced neurodegeneration.
ISSN: 0125-3832
Appears in Collections:Anatomy: National Journal Publications
Pharmacology: National Journal Publications

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